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KMID : 1023120100080010001
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Korean Journal of Aesthetic Society
2010 Volume.8 No. 1 p.1 ~ p.10
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Antioxidation activity and Inhibition of B16F10 melanoma cell from Moutan Cortex from Ethanol Extracts.
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Hur Sun-jung
Kim Kyoung-Young
Park Eun-Young
Jang A-reum
Yang Ki-Sook
Whang Wan-Kyunn
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Abstract
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Moutan Cortex extracts has been reported to have radical scavenging activity. On these facts, biological activity and whitening effect were examined to evaluate a bioactivity of the extracts of Moutan Cortex Radicis by extraction conditions as a possible functional cosmetic agent material. We prepared ethanol extracts. Fractionation is hexane and dichloromethane and ethyl acetate and butanol and water. This is measured DPPH assay, NBT/XO assay, tyrosinase assay and MSH-induced melanin production in B-16 cells and MTT assay. Ethyl acetate and butanol fractionation of Moutan Cortex Radicis showed dose-dependently anti-oxidant activity in DPPH, NBT/XO assay. Also, ethyl acetate fraction significantly inhibited tyrosinase activity and MSH-stimulated melanin production in B-16 cells. Therefore, these results suggest that ethyl acetate fraction of Moutan Cortex Radicis will be developed as a functional cosmetic agent, such as excellent whitening agent.
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KEYWORD
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Tyrosinase, Paeonia sulfruticosa Andrews, anti-oxidant, whitening, tyrosinase, B16F10 melanoma cell
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